Among the paintings of Raphael Santi (1483-1520) in which medical subjects are found, the boy in "The Transfiguration" is perhaps the most interesting. The painting was begun during the latter part of Raphael's life and remained unfinished at his death. DuBois Raymond, in a lecture in Berlin, 1890, called attention to the Magendie position of the eyes, as indicative of disease of the central nervous system. The boy's left hand is in a state of athetoid spasm. The photograph is by Alinari, from the original in the Vatican Gallery at Rome.