History.—A 5 year old white girl, who presented many interesting sociological as well as diagnostic problems, was admitted to the Duke Hospital on Dec. 4, 1930, with the complaint of menstruation since the age of 3 months and over-development.
The mother, 27 years of age, was living and well; menstruation had begun at the age of 14 years. The father, aged 27, was also living and well. Both parents were average in size. There was one other child in the family, a boy 4 years old, normal in size and development, and weighing 34 pounds (15.4 Kg.). There was no family history of any condition similar to the patient's.
The patient was born on July 28, 1925. Delivery was spontaneous at full term. The birth weight was 6¾ pounds (3.1 Kg.). The infant had a small amount of vaginal bleeding every two or three days from birth to the