October 1931, Vol 42, No. 4_PART_I >

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Case Reports | October 1931

XANTHOMATOSIS

H. B. METTEL, M.D.

Am J Dis Child. 1931;42(4_PART_I):858-863. doi:10.1001/archpedi.1931.01940160126010.

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As early as 1919, several writers¹ described a few cases of defects in the membranous bones occurring within certain other clinical manifestations. This syndrome has been grouped under such terms as the following: defects in the membranous bones, diabetes insipidus with unilateral exophthalmos, Niemann-Pick's disease, Christian's syndrome and Schüller's disease. In 1928, Rowland² made a careful study of the reports of these cases, and found that in each of these diseases the lipoid metabolism of the body was at fault. Instead of considering the diseases as separate and distinct clinical entities, Rowland considered them as different expressions of the same process and coined the term xanthomatosis to cover the entire group.

Rowland pointed out that such processes begin with an excess of lipoid in the body tissue. The lipoids act either on the vascular endothelium as irritants or on previously injured surfaces with a storage of lipoid in

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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METTEL HB. XANTHOMATOSIS. Am J Dis Child. 1931;42(4_PART_I):858-863. doi:10.1001/archpedi.1931.01940160126010.

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