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THE EFFECT OF ATROPINE ON THE BLADDER OF THE CHILD

SAMUEL AMBERG, M.D.; OTTO GROB, M.D.
Am J Dis Child. 1931;41(3):507-512. doi:10.1001/archpedi.1931.01940090024003.
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It is known that atropine can influence the bladder of animals. This activity displays itself rather in inhibition on stimulation of the pelvic nerves than in a primary effect on the bladder, particularly when it remains in situ and intact. Dennig1 mentioned that in the cat gradual relaxation follows slight contraction when atropine is administered, and Streuli2 observed such a relaxation of the isolated bladder in the rabbit. Definite effect of atropine on the bladder had not been demonstrated in man by exact methods of investigation before Amberg3 found that in some children atropine influenced the amplitude and frequency of the contractions of the bladder. Furthermore, it was demonstrated that the pressure of the inactive bladder could be diminished in some cases, and that such a bladder could hold more fluid than before.4 Since the publication of these results in abstract, Rose and Deakin5 have

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