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Am J Dis Child. 1930;40(6):1250-1261. doi:10.1001/archpedi.1930.01940060090008.
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The search for the etiology of the various forms of osteochondritis has led some authors to believe that rickets is a causative factor. Clinical and roentgenologic studies,1 however, have failed to substantiate this assumption. A review of the literature shows that the few desultory studies on the inorganic blood chemistry, based on a limited number of cases, have given conflicting results.

Seldowitz and Zimtbaum2 concluded that their study of the inorganic composition of the blood, that the efficacy of antirachitic therapy in their single case of Koehler's disease of the tarsal scaphoid and that the histologic evidence of osteoid tissue and irregular calcification gleaned from the literature pointed toward the rachitic nature of the disease. Durham and Outland,3 in a study of six cases of Perthes' disease and one case each of apophysitis of the os calcis and of Osgood-Schlatter's disease, concluded: (1) that Perthes' disease is


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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