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Am J Dis Child. 1930;39(3):544-548. doi:10.1001/archpedi.1930.01930150076009.
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As whooping cough causes many more deaths than diphtheria, measles or scarlet fever,1 it is important to know whether prophylactic injections of vaccine do or do not prevent the disease. The use of convalescent serum to control and prevent whooping cough was reported as early as 1901, as quoted by Griffith and Mitchell,2 and whooping cough vaccine has been in use for more than sixteen years. Fresh vaccine and stock vaccine have been used. While Huenekens3 believed that stock vaccines some months old are valueless, Mishulov, Oldenbusch and Scholl4 claimed that eight different stored preparations were tested at the end of four and one-half years and found to be highly potent, as measured by their power to stimulate specific antibodies in rabbits. Sauer and Hambrecht,5 in their excellent study of the problem, stated that as a prophylactic measure vaccines are lauded more by the practicing


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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