We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Scarlet Fever |


Am J Dis Child. 1928;35(6):991-1000. doi:10.1001/archpedi.1928.01920240038006.
Text Size: A A A
Published online


In a series of studies1 on the sensitivity of the skin to scarlatinal streptococcus filtrate toxin and its neutralizing antibody, the following facts have been observed:

  1. In the new-born, the skin was usually not sensitive to considerable amounts of scarlatinal toxin, and this lack of sensitivity was not due to the presence of antitoxin in the blood. Relatively few infants developed sensitivity during the early months of life, but by the end of the first year the skin had become sensitive in a large proportion. Although antitoxin was not demonstrable in many young infants whose skin was insensitive to toxin, in older children the lack of sensitivity was practically always accompanied by antitoxin in the blood.

  2. Hemolytic streptococci isolated from young infants with infections of the upper respiratory tract in certain instances formed a toxin which was neutralized by convalescent scarlet fever serum, but not by serum


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.