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Am J Dis Child. 1928;35(2):186-192. doi:10.1001/archpedi.1928.01920200018002.
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Many physicians have reported high percentages of successful vaccinations by the intradermal method (Starkey,1 Berney,2 Twyman,3 Wright4 and Simko5). Leiner and Kundrawitz6 vaccinated fifty children with 0.1 cc. of a 1:100 dilution of vaccine and obtained positive and feverless reactions in thirty-nine, no reactions in five and atypical reactions in six. Singer7 also claims that fever associated with intradermal vaccination is rare or of short duration, the reactions milder and the resultant scars less definite. Many authors (Kovacs,8 Frankenstein,9 Gettinger10 and Hoffman11) believe that there is a decrease in secondary infections. Three hundred and twenty-one of Twyman's 397 patients, or 80.9 per cent, had positive reactions. Wright vaccinated intradermally 227 patients who previously had been vaccinated unsuccessfully as often as from two to eight times, with 160 successful vaccinations (70.4 per cent). These patients were vaccinated concurrently with the


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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