Much uncertainty prevails concerning the changes in the concentration of sugar in the cerebrospinal fluid in disease. This is due in part to the divergence in the results obtained by various observers even with the cerebrospinal fluid of normal persons. Schloss and Shroeder,1 in their series of cases, found that the concentration of glucose in the cerebrospinal fluid varied from 50 to 134 mg. per hundred cubic centimeters. Wittengstein2 found from 45 to 60 mg. of glucose per hundred cubic centimeters and obtained high values for the sugar in the spinal fluid of diabetic patients. In the studies of Seham and Nixon,3 the average amount of sugar in the spinal fluid was 69 mg. per hundred cubic centimeters. In our series of human cases, we also obtained a marked fluctuation, which was between 40 and 194 mg. (table 1).
This marked variation led us to study the