September 1927, Vol 34, No. 3 >

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MICROPRECIPITATION TEST FOR SYPHILIS

M. G. PETERMAN, M.D.

Am J Dis Child. 1927;34(3):404-407. doi:10.1001/archpedi.1927.04130210079008.

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Originality is not claimed in proposing a microprecipitation test of blood serum and spinal fluid for syphilis. The Kahn¹ test is a modification of the Sachs-Georgi reaction,² an extract prepared according to the method of Neymann and Gager³ and a short period of incubation being used. The basis of most of the precipitation reactions in syphilis is Michaelis'⁴ observation that diluted alcoholic extract of a syphilitic liver added to heated syphilitic serum produces a precipitation. A review of the literature may be found in Kahn's book¹ and in an article by Kline and Young.⁵

The time-consuming complexity, the difficulty in standardization and the possible sources of error in the complement fixation blood test have stimulated a search for a more reliable and a simpler test. The Wassermann test is an indirect, empiric procedure requiring five different animal reagents for its completion: human serum (antibody),

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PETERMAN MG. MICROPRECIPITATION TEST FOR SYPHILIS. Am J Dis Child. 1927;34(3):404-407. doi:10.1001/archpedi.1927.04130210079008.

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