Postoperative leukocytosis was first described by George Schultz,1 in an article published in 1893. A number of confirmatory studies followed his publication of the fact that surgical operations on noninfected patients were followed by an increase in the blood leukocytes.
The more recent studies in this field include the work of Busse2 who, in 1905, studied patients after extraperitoneal gynecologic operations, and concluded that the leukocytosis was a normal sequel of such operations. He found that the increase in the leukocytes lasted for several days, and that their fall after this rise could easily be plotted to a practically standard graph.
Krumbhaar,3 in 1917, studied postoperative leukocytosis in the dog, and found that a considerable rise in the leukocytes followed all cutting operations, and occurred in a less degree after narcosis and hemorrhage. His studies led him to conclude that in this form of leukocytosis the new