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THE PRODUCTION OF A LOWERED CARBOHYDRATE TOLERANCE IN DOGS

FREDERICK F. TISDALL, M.D. (TOR.); T. G. H. DRAKE, M.B. (TOR.); ALAN BROWN, M.B. (TOR.)
Am J Dis Child. 1926;32(6):854-861. doi:10.1001/archpedi.1926.04130120051005.
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In a previous communication,1 it was shown that glucose injected into the blood stream of infants with diarrhea, infection or acute intestinal intoxication was not removed with the normal rapidity, and that this derangement of the carbohydrate metabolism was not primarily associated with a deficient production of insulin. In the present study, an attempt was made to determine what factors were responsible for this derangement.

The animals used were puppies. In the preliminary experiments it had been found that conditions which produced no change in adult animals produced profound changes in young animals. As the object of the experiment was to produce conditions similar to those encountered in infants if possible, the importance of the age of the animals used is at once apparent. The blood sugar concentration in normal puppies was determined after the intravenous administration of 10 cc. per pound of body weight of a 10 per

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