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PROGRESS IN PEDIATRICS |

THE PRACTICAL VALUE OF BIOLOGIC THERAPY IN THE PROPHYLAXIS AND TREATMENT OF SCARLET FEVER

JOHN A. KOLMER, M.D., D.Sc.
Am J Dis Child. 1926;32(4):556-563. doi:10.1001/archpedi.1926.04130100076011.
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Professor of Pathology and Bacteriology in the Graduate School of Medicine of the University of Pennsylvania

PHILADELPHIA  Since the Schick test has proved so reliable for determining susceptibility to diphtheria, and toxin-antitoxin mixtures have been so successful in vaccination against the disease—to say nothing of the value of diphtheria antitoxin in passive prophylaxis and treatment—it is no wonder that similar attempts have been made in the specific prophylaxis and treatment of scarlet fever. The Dicks discovered three years ago that the disease apparently was caused by a hemolytic streptococcus and its soluble or exogenous toxin. A large amount of investigation has been devoted to the skin test for susceptibility to scarlet fever, to vaccination with streptococcus toxin and to prevention and treatment with antiscarlet fever streptococcus serum. It is my purpose to summarize briefly their practical value and applications at the present time. I fully realize that our information is

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