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THE PROPHYLAXIS OF VARICELLA WITH VESICLE FLUID

ROY M. GREENTHAL, M.D.
Am J Dis Child. 1926;31(6):851-855. doi:10.1001/archpedi.1926.04130060092006.
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Vaccination of exposed patients with the contents of varicella vesicles is not new. In 1913 Kling1 was quite successful with this procedure. It has also been used with more or less favorable results by Handrick,2 Rabinoff,3 Michael4 and others. Lately, the use of convalescent varicella serum has been tried by Blackfan5 and by Weech,6 with satisfactory results. Hess and Unger7 reported excellent results in varicella prophylaxis with vesicle fluid injected intravenously. Vaccination with vesicle fluid, using the same technic as with smallpox vaccination, would seem to be the simplest procedure, and it has this advantage over convalescent serum prophylaxis in that an active instead of a passive immunity is obtained. During the past two years, I have had the opportunity of testing the efficacy of varicella vesicle fluid in checking the spread of this disease, and the results have been so satisfactory that

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