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Am J Dis Child. 1926;31(4):514-519. doi:10.1001/archpedi.1926.04130040057009.
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In recent years much interest and varying degrees of importance have been attached to the chloride content of the blood plasma.1 Hypochloremia has been noted in a number of such unrelated clinical conditions as severe superficial burns, pneumonia, war-gas poisoning, the pernicious vomiting of pregnancy and high intestinal obstruction.2 Closer study reveals the fact that in spite of their diverse pathology, these conditions all have one of two factors in common. There is either a circulating toxin of a split protein nature as in intestinal obstruction3 and burns,4 or there is a rapid and severe loss of fluids as in war-gas poisoning, pernicious vomiting and pneumonia. In some instances there is a combination of the two. It was therefore thought that a study of the chlorides in acute intestinal intoxication in which fluid loss and a split protein intoxication5 were both present would be of


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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