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URIC ACID AND CREATININ IN THE URINE OF INFANTS

O. S. ROUGICHITCH, M.D.
Am J Dis Child. 1926;31(4):504-513. doi:10.1001/archpedi.1926.04130040047008.
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URIC ACID  Medical literature abounds with publications concerning the uric acid excretion and its variations in relation to diet and to conditions of health and disease. Pediatric literature, however, gives but little information on the excretion of uric acid by infants. This is due chiefly to the difficulties encountered in collecting the infant's urine quantitatively. The published data we have found are summary and incomplete, and are often contradictory. The discrepancies apparent are probably referable to inaccurate measurements. Until quite recently, the methods for determining uric acid have not been satisfactorily dependable.We find that Lesné and Binet,1 in their publication, state that one can find 0.15 gm. of uric acid excreted in the urine of infants in twenty-four hours. They reported the figures of Kotscharowsky, showing the relationship between urinary uric acid and urea in the new-born and during the first months of life. These are seen in

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