Ichthyosis is characterized by dryness and scaliness of the skin, and in severe cases it bears a resemblance to the skin of fishes. Ichthyosis was recognized in the Middle Ages and was first accurately described by Willan in his work on cutaneous diseases (1796-1808). From time to time in the last four decades, reports of cases have appeared in which the symptoms have been ameliorated by the administration of thyroid extract, and others in which pathologic changes have been found in the thyroid gland.1
Clinical evidence has seemed to indicate a relationship existing between this disease and hypothyroidism. Consequently, the basal metabolism was determined on the following series of patients on whom the diagnosis of ichthyosis had been made by the Skin Department of the Massachusetts General Hospital.
REPORT OF CASES
—H. K., a girl, aged 9 years, whose family and past history were unimportant, had suffered