The term "acidosis" designates the lowering of the alkali reserve of the body caused by abnormal production or retention of acids. The types of acidosis most clearly distinguished are: (1) the acetone-body type, due to aceto-acetic and betahydroxybutyric acids; and (2) the phosphoric acid type, due to to the retention of acid phosphate. In this paper, evidence for the existence of a type of acidosis due to lactic acid will be presented.
The most generally accepted view at present regarding the origin and fate of lactic acid in the tissues appears to be the following: whenever the tissues perform mechanical work, d-lactic acid is suddenly formed from a precursor, lactacidogen (apparently a derivative of hexosediphosphoric acid) and the alkali reserve in the active tissues falls. During the ensuing period of rest, the lactic acid normally is removed in several ways: (1) by oxidation, (2) by synthesis to glycogen or