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UROBILIN EXCRETION IN THE ANEMIAS OF INFANTS AND CHILDREN

MURRAY H. BASS, M.D.; BERNARD S. DENZER, M.D.; HAROLD HERMAN, M.D.
Am J Dis Child. 1924;27(5):433-437. doi:10.1001/archpedi.1924.01920110014003.
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It is now well established that the amount of urobilin and urobilinogen in the stools is a rough index of the amount of blood destruction going on in the body. Since no large number of cases of anemia in children has been studied as regards their urobilin excretion, it seemed worth while to undertake such a study. Our plan was to determine, if possible, whether certain of the forms of anemia met with in childhood might be differentiated from others by their pathogenesis. In other words, are there some forms of anemia in infancy characterized by excessive blood destruction? It is well known that in the anemia seen in cases of hemolytic icterus, there is excessive blood destruction, evidenced by an unusually large amount of urobilin in the stools and urine. Hemolytic icterus is the best example of an anemia due to blood destruction and it seemed likely that other

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