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Am J Dis Child. 1924;27(2):110-112. doi:10.1001/archpedi.1924.01920080017003.
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The pathologic examination in a case of generalized miliary tuberculosis in childhood shows why this disease is nearly always fatal. There is a softened focus of tuberculosis, usually in a lymph node, which has discharged into a blood vessel, not once, but several times, the cavity having undoubtedly filled. Evidence of repeated infection is found in the size of the resultant tubercles. There are crops of different sizes, but the tubercles that belong to one crop are of approximately the same size. This indicates an eruption of tubercle bacilli into the blood stream at different intervals. The discharge of tubercle bacilli may be so overwhelming and produce so extensive and generalized an infection as to prove fatal in a short time. But if it does not, successive discharges of tubercle bacilli can hardly be borne; and, from the nature of the lesion in the tuberculosis focus, successive discharges are the


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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