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DYSKERATOSIS DIFFUSA CONGENITA

CORNELIA de LANGE, M.D.; J. C. SCHIPPERS, M.D.
Am J Dis Child. 1922;24(3):186-191. doi:10.1001/archpedi.1922.04120090009002.
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REPORT OF CASE 

History.  —The infant was born normally at term. It cried directly after birth and the meconium and urine were evacuated before the child had anything by mouth. It is the first child of healthy parents. There is no history of miscarriages or of tuberculosis.

Examination.  —When 1 day old the baby was examined and it was noted that the skin had a yellow brown color and resembled parchment. The epidermis was for the greater part detached from the underlying layers. There was no sign of trauma except in the groins, which showed some excoriation, and where the underlying stratum was traumatized, the corium was laid bare.There was much secretion from the vagina. The face was quite devoid of expression and resembled a plaster cast. The eyelids of both eyes showed signs of ectropion. The conjunctiva was of a bright red color. The mouth was very large

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