Jeans1 has reviewed the literature on this subject up to April, 1920. It is the object of the present review to bring the literature to date (December, 1921). A brief survey suffices to show the extent to which contributions from the laboratory predominate over those from clinic and practice. The reason for this is not far to seek. Syphilis, hereditary or acquired, is a disease in whose investigation and partial conquest the laboratory has played an important, an essential part. Excepting statistical reports, there are relatively few clinical observations or contributions to symptomatology. Clearly, serology, chemistry and pathology offer the widest fields for original endeavor in this disease.
Jeans and Cooke2 made a study of the placentas, and of the Wassermann reactions of the cord blood of a series of 2,030 unselected infants in St. Louis. By examining the blood of 389 of these infants after 2