These investigations were carried out to determine the functional pathology of the nephritides in children. Little data was found in the literature when this work was begun. Since that time Hill1 has reported on some fairly extensive work along this line. The preponderance of acute over chronic cases in childhood affords an opportunity for the study of the disease at its inception which is unique in civilian practice. All cases of nephritis admitted to the wards were placed in my charge and in this way close cooperation between the ward and the laboratory was maintained.
Infections, often apparently insignficant, were the most important etiologic factors in a series of twenty-six cases.The tonsillitis was only revealed by the examination of the tonsils in some cases, no complaint of sore throat having been made. Cultures from the tonsils in two of these cases gave pure cultures of Streptococcus hemolyticus.Blood