Czerny and Keller1 mention that Mesnil found sugar occasionally in the urine of infants during the first few days of life, and Nothman2 found sugar in the urine of premature infants. The presence of sugar was shown by reduction tests, and in the case of Nothman the osazone was prepared which indicated the presence of lactose. By using the Benedict-Osterberg3 method, Greenthal4 showed that the urine of all infants contains sugar. This would be expected from the results obtained by Benedict, Osterberg and Neuwirth.5 These authors found determinable quantities of sugar at all times, both in the urine of normal dogs, and those fasting for four-day periods, and in the urine of adults.
Thanks to the kindness of Dr. Sauer, we were able to obtain the urine of a series of new born infants for sugar determination.
The urine was collected during the period preceding