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Am J Dis Child. 1920;20(6):556-561. doi:10.1001/archpedi.1920.01910300096008.
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It has long been considered probable that the urine of normal individuals contains a reducing sugar. Benedict, Osterberg and Neuwirth1 recently demonstrated the constant presence of sugar in normal urine and devised a method for its quantitative determination. They found that the amount of sugar in the urine was directly influenced by the quantity of sugar ingested. They also demonstrated that the urine sugar can be separated into two fractions by fermentation with yeast, a fermentable and a non-fermentable portion.2

During the course of work in this laboratory on the sugar tolerance of infants, a number of determinations of urine sugar have been made. These determinations have led to observations which seem of sufficient interest to report.

Technic.—The infants on whom observations were conducted were all practically normal in the sense of being free from infections or gastro-enteric disturbances. Many were of normal weight, a few were


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