The subject of this report is a child, aged 4½ years. There are two other children in the family who are normal. The family history is in other respects negative.
This child was perfectly well and had no symptoms until early in November, 1917. At that time she was vaccinated against smallpox. The vaccine used was the same as that employed in many cases without any unusual results. The reaction from the vaccination was violent with high temperature and the involvement of the glands in the groin. A few days after the vaccination had subsided her face became red and swollen about the eyes and she complained of a little stiffness in bending her knees. From that time until early in January there was a steady progress in the condition, until at the present time all the joints of the body are involved including the spine. This condition