C. E., 9 years old, entered the hospital because of sudden enlargement of the right knee. He gave a history of repeated attacks of purpura, at times associated with vomiting and fever. The coagulation time of the blood was found to be two and one-half hours. Shortly after entrance he had a marked attack of purpura, with vomiting and fever; and during his stay in the hospital he had many spontaneous and subcutaneous hemorrhages. His brother, aged 19, was also under observation during part of this time for spontaneous hemorrhage into one knee.
A history of bleeding was obtained as follows: Of this family of twelve children, six girls and six boys, three of the boys were bleeders, one dying in infancy from hemorrhage. The maternal grandmother was a bleeder, and was one of ten children, four girls and six boys, three of whom were bleeders, herself and two brothers.