Accepted for Publication: November 11, 2011.
Published Online: March 5, 2012. doi:10.1001/archpediatrics.2011.1559
Author Contributions: Dr Vaarala was the principal investigator. All authors had full access to the data. The FINDIA Study Group had the final responsibility for the decision to submit the report for publication. Study concept and design: Vaarala, Ilonen, Virtanen, Tossavainen, Komulainen, Lounamaa, Åkerblom, and Knip. Acquisition of data: Vaarala, Ilonen, Ruohtula, Pesola, Härkönen, Järvenpää, Lounamaa, and Knip. Analysis and interpretation of data: Vaarala, Ilonen, Virtanen, Koski, Poussa, Järvenpää, and Knip. Drafting of the manuscript: Vaarala and Knip. Critical revision of the manuscript for important intellectual content: Ilonen, Ruohtula, Pesola, Virtanen, Härkönen, Koski, Kallioinen, Tossavainen, Poussa, Järvenpää, Komulainen, Lounamaa, Åkerblom, and Knip. Statistical analysis: Poussa. Obtained funding: Vaarala. Administrative, technical, and material support: Vaarala, Ilonen, Ruohtula, Härkönen, Koski, Kallioinen, Tossavainen, Komulainen, Lounamaa, and Knip. Study supervision: Vaarala, Ilonen, Virtanen, Komulainen, Lounamaa, and Knip.
Financial Disclosure: Dr Tossavainen and Mr Kallioinen are employed by Valio Ltd. Drs Vaarala and Tossavainen are inventors on the patent EP1124436 owned by Valio Ltd.
Funding Support: Support for this study was provided by the Academy of Finland, Finnish Diabetes Research Foundation, Valio Ltd, TEKES, Päivikki ja Sakari Sohlberg Foundation, Sigrid Juselius Foundation, and the Finnish Foundation for Pediatric Research.
Role of the Sponsor: The study sponsor, Valio Ltd, was involved in the design of the study and writing of the report. The sponsor had no role in data collection, data analysis, or data interpretation. The statistical analysis was performed by an independent statistician (Ms Poussa).
Online-Only Material: This article is featured in the Archives Journal Club. Go here to download teaching PowerPoint slides.
Additional Contributions: Anne Björk, MSc, Sirpa Nolvi, RN, Nina Narsakka, MSc, and Minna Matikainen, RN, contributed excellent work with the participating families. We deeply thank all participating children and their families for valuable collaboration.