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Role of Waist Measures in Characterizing the Lipid and Blood Pressure Assessment of Adolescents Classified by Body Mass Index

Michael Khoury, MD; Cedric Manlhiot, BSc; Stafford Dobbin, MB, FCFP; Don Gibson, NP-PHC; Nita Chahal, RN, MN, NP-Peds; Helen Wong, RD; Jolie Davies, BDes, MA; Karen Stearne, BSc; Amanda Fisher, CAT; Brian W. McCrindle, MD, MPH
Arch Pediatr Adolesc Med. 2012;166(8):719-724. doi:10.1001/archpediatrics.2012.126.
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Objective  To determine if the interaction of waist circumference percentile and waist to height ratio (WHtR) with body mass index (BMI) may serve to provide further risk specification in the lipid and blood pressure assessment of adolescents beyond BMI classification.

Design  Population-based, cross-sectional study. Data collected during the 2009-2010 academic school year.

Setting  Geographically and administratively defined Niagara Region, Ontario, Canada. Data collected in school, during subjects' mandatory physical education class. Part of the Heart Niagara Inc Healthy Heart Schools' Program.

Participants  Entire population of grade 9 (14- and 15-year-old) students in the Niagara Region, Ontario. Four thousand eight hundred eighty-four students enrolled in grade 9 during the study period, of which 4104 participated (51% male) and 3248 (79%) had complete data.

Main Outcome Measures  Nonfasting lipid values and blood pressure categories in subjects categorized based on BMI/waist circumference percentile and BMI/WHtR.

Results  The associations between blood pressure, lipid profile, and measures of adiposity (BMI alone, BMI/waist circumference percentile, and BMI/WHtR) were statistically significant but had a limited strength and were not statistically significant from each other. For overweight and obese subjects, increased WHtR categories were associated with worsened lipid profile and increased odds of hypertension both relative to subjects with both normal BMI and normal WHtR and subjects with normal WHtR within each BMI category.

Conclusion  Waist measures should be included in the screening and assessment of overweight and obese adolescents.

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Grahic Jump Location

Figure 1. Mean values of lipid variables across body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) and waist to height ratio (WHtR) categories, adjusted for age and sex. Normal: BMI less than the 85th percentile; overweight: BMI in the 85th to less than the 95th percentile; obese: BMI in the 95th percentile or more; light gray: WHtR less than 0.5; dark gray: WHtR 0.5 to less than 0.6; and black: WHtR 0.6 or more. *Statistically significant values (P < .05) relative to the BMI less than the 85th percentile and WHtR less than 0.5 category. †Statistically significant values (P < .05) relative to subjects with a WHtR less than 0.5 within that given BMI category. SI conversion factor: To convert total cholesterol and high-density lipoprotein (HDL) cholesterol to milligrams per deciliter, divide by 0.0259.

Place holder to copy figure label and caption
Grahic Jump Location

Figure 2. Odds ratios for a higher blood pressure category (normal vs prehypertension vs hypertension) for the body mass index (BMI) and waist to height ratio (WHtR) categories, adjusted for age and sex. Only the last 2 categories were significantly different than normal (odds ratio, 3.2; P = .003; odds ratio, 7.2; P < .001), and both were different from each other (odds ratio, 2.3; P = .001). Normal: BMI less than the 85th percentile; overweight: BMI in the 85th to less than the 95th percentile; obese: BMI in the 95th percentile or more. Error bars represent the 95% confidence interval.

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