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Determination of Tobacco Smoke Exposure by Plasma Cotinine Levels in Infants and Children Attending Urban Public Hospital Clinics

Delia A. Dempsey, MD, MS; Matthew J. Meyers, MPH; Sam S. Oh, PhD, MPH; Elizabeth A. Nguyen, BS; Elena Fuentes-Afflick, MD, MPH; Alan H. B. Wu, PhD; Peyton Jacob, PhD; Neal L. Benowitz, MD
Arch Pediatr Adolesc Med. 2012;166(9):851-856. doi:10.1001/archpediatrics.2012.170.
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Objective  To determine the prevalence of secondhand smoke (SHS) exposure among infants and young children who received preventive care at pediatric preventative care clinics associated with an urban public hospital. Cotinine, a metabolite of nicotine, has been used to study SHS exposure in population-based studies of children 3 years of age or older.

Design  Retrospective study using a convenience sample.

Setting  Urban county pediatric primary care clinics in San Francisco, California.

Participants  A total of 496 infants and children (mean [SD] age, 2.4 [1.9] years).

Interventions  Discarded plasma samples (which were routinely collected for lead screening) were tested, and medical records were reviewed, for SHS exposure.

Main Outcome Measure  Secondhand smoke exposure based on cotinine plasma level and history of exposure in the medical record.

Results  Thirteen percent of parents reported that their child was exposed to SHS, yet biochemical testing detected cotinine in 55% of samples, at a geometric mean (SD) of 0.23 (3.55) ng/mL. There were no significant sex or age differences. African American children had much higher mean cotinine levels than did Latino children (geometric mean difference, 6.07 ng/mL [95% CI, 4.37 to 8.43 ng/mL]).

Conclusion  In a city with a low smoking rate (12%) and public smoking bans, we documented 55% exposure among infants and young children, using a plasma biomarker, compared with 13% exposure reported by parents. Because SHS is associated with significant respiratory diseases and parents underreport exposure, routine biochemical screening should be considered as a tool to identify and reduce SHS exposure.

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Figures

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Grahic Jump Location

Figure 1. Histogram of plasma cotinine levels for subjects with detectable cotinine levels. Data on the x-axis are plotted on a logarithmic scale.

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Grahic Jump Location

Figure 2. Box plots of plasma cotinine levels in subjects with cotinine levels greater than or equal to the limit of quantitation, by race/ethnicity.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

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