A 31-month-old Hispanic boy presented for evaluation of possible retinoblastoma in the right eye. At 22 months of age, strabismus had developed. There was no history of trauma. Three months later, examination showed total retinal detachment with the retina visible immediately posterior to the lens (Figure, A and B). Visual acuity was reduced to light perception in the right eye. With the left eye, he could fix and follow an object normally. The anterior segment of the right eye was unremarkable except for xanthocoria (yellow pupil) from an exudative retinal detachment. Examination of the left eye was unremarkable. He was treated with anterior chamber injections of bevacizumab on a monthly basis for 5 months to resolve the retinal detachment.