Accepted for Publication: May 28, 2011.
Author Contributions: Dr Andraweera had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Andraweera, Dekker, McCowan, North, and Roberts. Acquisition of data: Andraweera, Dekker, Thompson, Nowak, Zhang, North, and Roberts. Analysis and interpretation of data: Andraweera, Dekker, McCowan, North, and Roberts. Drafting of the manuscript: Andraweera. Critical revision of the manuscript for important intellectual content: Andraweera, Dekker, Thompson, Nowak, Zhang, McCowan, North, and Roberts. Statistical analysis: Andraweera. Obtained funding: Dekker, McCowan, North, and Roberts. Administrative, technical, and material support: Andraweera, Dekker, Thompson, Nowak, Zhang, and Roberts. Study supervision: Dekker, McCowan, North, and Roberts.
Financial Disclosure: Dr North has a consultancy relationship with Pronota and Alere and declares patent PCT No. WO/2009/108073.
Funding/Support: The SCOPE study was supported by the South Australian government, the Foundation for Research Science and Technology, the Health Research Council of New Zealand, and the Auckland District Health Board Charitable Trust. Genotyping was funded by the National Health and Medical Research Council Australia and the Channel 7 Children's Research Foundation. Dr Andraweera holds an Australian Leadership Award funded by the Australian government.
Role of the Sponsors: The study sponsors had no role in the study design, the data analysis and interpretation, or the writing of this report.
Additional Contributions: Denise Healy, RN, RM, and Rennae Taylor, MHSc, coordinated the SCOPE study in Adelaide and Auckland, respectively; MedSciNet and Eliza Chan, MSc, provided support for the database; and the Australian Genome Research Facility conducted the genotyping. We thank the SCOPE families who generously consented to participate in this study and the SCOPE study midwives at both centers.