When seen at age 5 years, he still had widespread chronic eczema. In addition, erythematous and infiltrative lesions surmounted by scales and crusts were evident in a circinate pattern (Figure). Scalp and eyebrow hair did not show any abnormality clinically or on dermatoscopic and microscopic examination. Multiple skin cultures isolated methicillin-resistant Staphylococcus aureus. Serum IgE and blood eosinophil levels were elevated; dosage of specific IgE showed positivity toward several airborne and food allergens. Topical emollients, corticosteroids (hydrocortisone butyrate, triamcinolone), calcineurin inhibitors (tacrolimus, pimecrolimus), bleach baths, and nasal mupirocin achieved only mild improvement of cutaneous lesions. The diagnosis was achieved by genetic testing.