This multicenter case-control observational study of children with acute gastroenteritis reports that severe rotavirus gastroenteritis was virtually absent among US children who had a genetic polymorphism that inactivates FUT2 expression on the intestinal epithelium.
This longitudinal study tested whether genetic risk for obesity is associated with accelerated weight gain in middle childhood (ages 4-8 years) and whether genetic association with accelerated weight gain is mediated by appetite traits.
Llewellyn et al test the hypothesis that satiety responsiveness is an intermediate behavioral phenotype associated with genetic predisposition to obesity in children. From a twin cohort, they included 2258 unrelated children, one randomly selected from each twin pair, and assessed a polygenic risk score, adiposity, and satiety responsiveness.
Hobbs and coauthors report on the current state of the genetic epidemiology of birth defects and comment on future challenges and opportunities. They consider issues of study design and discuss common variant approaches, including candidate gene studies and genome-wide association studies. They also discuss the complexities embedded in exploring interactions between genes and the environment.
This cohort study compares estimates of association between parental acetaminophen use and child conduct disorders for maternal prenatal, maternal postnatal, and partner use to understand the degree to which unmeasured behavioral variables might account for observed associations.
This literature review provides an update on the current knowledge about Kawasaki disease as well as recent advances in its diagnosis and treatment.
This recommendation statement from an expert panel describes a set of best practices for the diagnosis and evaluation of infants with Robin sequence.