This review investigates current literature for treatment recommendations for cardiometabolic risk factors associated with polycystic ovary syndrome and finds potential for metformin and estrogen-progestin dual therapy, although longitudinal studies are warranted to determine its long-term effect on cardiovascular health.
This cross-sectional study evaluates whether obese adolescents with metabolic syndrome have retinal vessel alterations and cerebral white matter microstructural damage.
This retrospective cohort study examines the prevalence of birth defects among liveborn infants conceived with and without assisted reproductive technology.
Using MEDLINE and EMBASE database search results, this meta-analysis of 10 randomized clinical trials provides a systematic review of the effects of metformin use on height in 562 children and adolescents comprising intervention and control groups.
This retrospective observational study reports that the risk for incident type 2 diabetes mellitus was increased among youths initiating second-generation antipsychotics and was highest in those concomitantly using antidepressants.
This prospective cohort study reports that increasing body mass index and male sex increase relative risk of specific cardiovascular disease risk factors and suggests that even among severely obese adolescents, recognition and treatment of cardiovascular disease risk factors is important to help limit further progression of disease.
McDonagh and colleagues evaluated the effectiveness and safety of metformin for treating obesity in children aged 18 years or younger without a diagnosis of diabetes mellitus.