This cohort study tests the hypotheses that maternal folate concentrations can affect child metabolic health and that sufficient maternal folate concentrations can mitigate prepregnancy obesity-induced child metabolic risk.
Gupta and coauthors compare high-frequency oscillatory ventilation with conventional mechanical ventilation in children with acute respiratory failure.
Liu et al evaluate the association between blood lead concentrations and behavioral problems in Chinese preschool children.
This review investigates current literature for treatment recommendations for cardiometabolic risk factors associated with polycystic ovary syndrome and finds potential for metformin and estrogen-progestin dual therapy, although longitudinal studies are warranted to determine its long-term effect on cardiovascular health.
This review article examines the current state of newborn screening for inborn errors of metabolism (IEMs), recent advances in therapy for IEMs, and opportunities for further exploration and discovery.
Inge and colleagues conducted a prospective, multisite observational study to assess the preoperative clinical characteristics and perioperative safety outcomes of severely obese adolescents undergoing weight-loss surgery. Michael G. Sarr, MD, provided a related editorial.
This retrospective observational study reports that the risk for incident type 2 diabetes mellitus was increased among youths initiating second-generation antipsychotics and was highest in those concomitantly using antidepressants.
This Review describes the endocrine effects of inhaled corticosteroids in children and the properties of the various formulations as they relate to these adverse outcomes.
Barnhart et al performed a retrospective, observational cohort study to compare the effect of fundoplication at the time of gastrostomy tube (GT) placement vs GT placement alone on subsequent reflux-related hospitalizations in 4163 infants with neurological impairment born between 2005 and 2010 at 42 US children’s hospitals.