This multicenter case-control observational study of children with acute gastroenteritis reports that severe rotavirus gastroenteritis was virtually absent among US children who had a genetic polymorphism that inactivates FUT2 expression on the intestinal epithelium.
In a 6-year (2006-2012) prospective cohort study, Cristofori and coauthors assess the prevalence of celiac disease among children with abdominal pain–related functional gastrointestinal disorders classified according to the Rome criteria. See editorial by Squires et al.
Guandalini and Assiri review how celiac disease is triggered by the ingestion of gluten in genetically predisposed individuals. Diagnosis requires an intestinal biopsy, and a strict gluten-free diet must be followed.