This Viewpoint discusses the specific areas that should be considered by global investigators when collaborating on the development of drugs for neonatal patients.
Momper et al compared US Food and Drug Administration–approved adult and adolescent drug dosing and assessed the utility of allometric scaling for the prediction of drug clearance in the adolescent population.
This cohort study examines if use of antenatal corticosteroids is associated with improvement in major outcomes in extremely preterm multiples.
Morriss et al assess the association between surgery during the initial hospitalization and death or neurodevelopmental impairment of very low-birth-weight infants. See the editorial by Williams et al.
This Review describes the endocrine effects of inhaled corticosteroids in children and the properties of the various formulations as they relate to these adverse outcomes.
Meador et al examined the effects of antiepileptic drug exposure via breastfeeding on cognitive functions at age 6 years among 181 children for whom both breastfeeding and IQ data were available. All mothers in this analysis continued taking drug after delivery. Differential Ability Scales IQ was the primary outcome. See the editorial by Harden.
Field et al investigate whether males with psychiatric symptoms related to eating and concern with physique are more likely to become obese, to start using drugs, to consume alcohol frequently, or to develop high levels of depressive symptoms.
This systematic review and meta-analysis reports on the self-reported reasons why children and youth around the world become street-involved.
This cohort study assesses the use and type of infertility treatment in relation to children’s development through age 36 months.
This cohort study investigates associations between nonmedical use of opioids, sedatives, or stimulants, and suicidal ideation and attempts among Chinese adolescents.
This Viewpoint discusses how the FDA can build upon the deeming rule to further protect youth by regulating e-cigarette advertising and flavors.
This Viewpoint discusses the need for development of pediatric medical devices.
This systematic review discusses the outcomes of drug prevention programs used in middle schools as shown by independent evaluations.
This systematic review of the effects of obesity on drug disposition in children shows that clinically significant pharmacokinetic alternations are common in obese children. See also the Editorial by Gillman and Block.
Laughon et al quantify progress made in neonatal studies and neonatal information in product labeling as a result of recent legislation. See related editorial by Stiers and Ward.