This cohort study examines whether metabolomics can distinguish healthy volunteers from trauma patients and quantify changes in catabolic metabolites over time after traumatic injury.
Gall et al examine the impact of 2 different surgical techniques, standard pancreaticoduodenectomy and no-touch isolation pancreaticoduodenectomy, on tumor behavior and outcome in patients with pancreatic cancer by using circulating tumor cells as biomarkers.
Bagaria et al use as an example the triple-negative phenotype defined by the absence of estrogen
receptor, progesterone receptor, and human epidermal growth factor 2 to examine whether such
inclusion improves the prognostic accuracy of TNM staging for breast cancer.
In a randomized controlled experiment, Kovalenko and Basson determine whether schlafen 3 (but not other schlafen proteins) act in vivo and whether its effects are limited to the small intestine.
This study evaluates the association between preoperative use of narcotics and postoperative outcomes in patients with Crohn disease.
Batchu et al determine whether generating melanoma antigen family A, 3 (MAGE-A3), a tumor-specific cancer-testis antigen, as a fusion protein with cell-penetrating domain will enhance the cytosolic bioavailability of MAGE-A3. Berger provides discussion in a related Invited Commentary.