This cohort study evaluates the trend of antibiotic use in very low-birth-weight infants across Canada and the association between antibiotic use rates and mortality and morbidity among neonates without culture-proven sepsis or necrotizing enterocolitis.
This population epidemiology study describes the incidence and clinical characteristics of Staphylococcus aureus bacteremia in children in Australia and New Zealand between 2007 and 2012.
This study evaluates whether delay in the initiation of antimicrobial therapy for pediatric febrile urinary tract infections is associated with the occurrence and severity of renal scarring.
This cohort study examines whether early-life antibiotic use in children is associated with the long-term effects of breastfeeding on weight development and lifetime antibiotic use.
This ongoing cohort study reports that early probiotic supplementation may reduce the risk of islet autoimmunity in children at the highest genetic risk of type 1 diabetes mellitus.
This Viewpoint reports on the antimicrobial stewardship programs that have been created in many institutions in response to the overuse of antibiotics that has been implicated as a contributor to childhood morbidities such as asthma and obesity.
This retrospective cohort study suggests that clinicians reconsider the practice of treating otherwise healthy children with acute osteomyelitis with prolonged intravenous antibiotics when an equally effective oral alternative exists.
This cohort study reports that repeated exposure to broad-spectrum antibiotics in children at ages 0 to 23 months is associated with early childhood obesity.
Beyerlein et al examine whether early, short-term, or cumulative exposures to episodes of infection and fever during the first 3 years of life were associated with the initiation of persistent islet autoimmunity in children at increased risk for type 1 diabetes mellitus.
Antimicrobial stewardship (AS) can prevent emergence of antibiotic resistance while improving patient outcomes and safety. Hyun et al review the literature for strategies to implement AS programs and identify barriers and challenges.